Preventing Panic


Sometimes, during the first session, a patient will feel anxiety, panic, and stress. These are some steps to take to minimize that risk.

It’s important to create a supportive and calming environment for patients undergoing their first therapeutic ketamine session. The following strategies can help to mitigate anxiety or panic during the treatment:

  1. Pre-session preparation: Educate the patient about the process, potential effects, and what to expect during the session. Address any concerns or fears they might have. This can help reduce anxiety and promote a sense of preparedness.
  2. Set and setting: Create a comfortable, quiet, and relaxing environment for the session. Dim lighting, comfortable seating or lying arrangements, and a familiar or soothing ambiance can help the patient feel more at ease. The presence of a trusted and experienced therapist or healthcare professional can provide additional reassurance.
  3. Controlled breathing techniques: Encourage the patient to practice deep, slow, and controlled breathing during the session. This can help reduce anxiety, lower heart rate, and promote relaxation.
  4. Mindfulness and grounding techniques: Guide the patient through mindfulness exercises or grounding techniques if they experience anxiety or panic. These methods can help them refocus their attention on the present moment and regain a sense of control.
  5. Verbal reassurance: Offer gentle reassurance and support throughout the session. Remind the patient that the experience is temporary and that they are in a safe environment.
  6. Adjust the dosage: In consultation with a healthcare professional, consider starting with a lower dose of ketamine for the first session to minimize the intensity of the experience. The dosage can be adjusted in subsequent sessions based on the patient’s response and comfort level.
  7. Music: Playing soft, calming, or instrumental music during the session can help create a more relaxing atmosphere and serve as a positive focus for the patient.
  8. Presence of a support person: If the patient feels more comfortable having a trusted friend or family member present during the session, accommodate this request whenever possible.
  9. Follow-up and integration: After the session, provide an opportunity for the patient to discuss and process their experience with a therapist or healthcare professional. This can help them integrate the experience and reduce anxiety about future sessions.

Remember that each patient is unique, and their needs and preferences may vary. Tailoring the approach to the individual can help ensure the most positive and effective therapeutic ketamine experience.


Aan Het Rot, M., Zarate, C. A., Charney, D. S., & Mathew, S. J. (2012). Ketamine for depression: where do we go from here? Biological Psychiatry, 72(7), 537-547.

Dore, J., Turnipseed, B., Dwyer, S., Turnipseed, A., Andries, J., Ascani, G., … & Sutherland, S. (2019). Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy. Journal of Psychoactive Drugs, 51(2), 189-198.

Niciu, M. J., Henter, I. D., Luckenbaugh, D. A., Zarate, C. A., & Charney, D. S. (2014). Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds. Annual Review of Pharmacology and Toxicology, 54, 119-139.

Short, B., Fong, J., Galvez, V., Shelker, W., & Loo, C. K. (2018). Side-effects associated with ketamine use in depression: a systematic review. The Lancet Psychiatry, 5(1), 65-78.

Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., … & Sanacora, G. (2018). The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis. American Journal of Psychiatry, 175(2), 150-158.


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John M.

This is what’s keeping me from starting. My fear of fear. Having a panic attack. I read earlier today someone having a terrible experience just from a Joyous 15mg troche. So I guess it can happen even on psycholytic doses? I was hopeful until I dig in and read more and more (panic) experiences. Now I’m stuck and distraught over the decision to start and if I even can.

John