Dosing for ketamine varies greatly depending on the route of administration and the specific goals of treatment. However, it is essential to note that a qualified healthcare professional should always determine your dosages based on your needs and medical history. The dose that produces the best response for each patient can only be determined by titrating the patient from lower to higher doses and observing the response.

Never vary your doses without consulting your provider and modifying your treatment plan.

Note that doses are intertwined with bioavailability, as the amount of ketamine introduced to the body ultimately results in the risk present to the bladder. Lower doses of ketamine are more bioavailable depending on their delivery means. Lower doses mean less ketamine and its metabolites reach the bladder, reducing the risk of harm. Here are some general guidelines for low, medium, and high doses of ketamine for various routes of administration:

Intravenous (IV):

  • Low: 0.1-0.45 mg/kg
  • Medium: 0.45-0.7 mg/kg
  • High: 0.7-1.0 mg/kg

Intramuscular (IM):

  • Low: 0.12-0.6 mg/kg
  • Medium: 0.6-0.85 mg/kg
  • High: 0.85-1.4 mg/kg


  • Low: 0.5-1 mg/kg
  • Medium: 1-3 mg/kg
  • High: 3-5 mg/kg

Nasal spray: (varies depending on the concentration of the solution)

  • Low: 2-3 sprays (approximately 20-30 mg)
  • Medium: 4-6 sprays (about 40-60 mg)
  • High: 7-9 sprays (about 70-90 mg)


  • Low: 50-75 mg
  • Medium: 100-150 mg
  • High: 200-300 mg

Rapid dissolve tablets:

  • Low: 50-75 mg
  • Medium: 100-150 mg
  • High: 200-300 mg


  • Low: 50-75 mg
  • Medium: 100-150 mg
  • High: 200-300 mg


  • Low: 25-50 mg
  • Medium: 50-100 mg
  • High: 100-200 mg


  • Low: 25-50 mg
  • Medium: 50-100 mg
  • High: 100-200 mg

Please note that these are general guidelines, and individual dosing will vary. A patient new to ketamine will respond more strongly to lower doses than a patient undergoing some length of the treatment period. A qualified healthcare professional should always determine and administer the exact dosages based on a patient’s needs and medical history.

Andrade, C. (2017). Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency? The Journal of Clinical Psychiatry, 78(7), e852-e857. Retrieved from

Williams, N. R., Heifets, B. D., Blasey, C., Sudheimer, K., Pannu, J., Pankow, H., … & Schatzberg, A. F. (2018). Attenuation of antidepressant effects of ketamine by opioid receptor antagonism. American Journal of Psychiatry, 175(12), 1205-1215. Retrieved from

Domino, E. F., Chodoff, P., & Corssen, G. (1965). Pharmacologic Effects of CI-581,a New Dissociative Anesthetic, in Man. Clinical Pharmacology & Therapeutics, 6(3), 279-291. Retrieved from

Notify of

Newest Most Voted
Inline Feedbacks
View all comments

Link to paper by Andrade no longer works. Correct link:

My previous comment re: IV & IM dosage still stands. 1-3 mg/kg administered IM, especially at the high end of range, is the range for anesthesia for many – not a medium dose for depression treatment. Please correct.


IM 93% bioavailability as compared to IV being 100%, IM ranges should be closer to IV ranges.

It looks to me that IM ranges currently listed (Low: 0.5-1 mg/kg; Medium: 1-3 mg/kg; High: 3-5 mg/kg) are accidental c&p of subcutaneous ranges, where bioavailability is much lower.

Appreciate your work putting this together, BTW! Your post on Reddit was a great resource to me before I started treatments last Summer.