Therapeutic ketamine may cause itchy eyes in some people as a side effect. Ketamine is an NMDA receptor antagonist with various effects on the central nervous system. The exact mechanism behind ketamine-induced itchy eyes is not well-established. However, it could be related to histamine release or other inflammatory mediators known to cause itching.
Histamine is a chemical involved in immune responses and can cause itching, redness, and swelling. Ketamine has been reported to cause histamine release in some cases, which might contribute to itchy eyes in sensitive individuals.
Because it is a histamine response, over-the-counter anti-histamine eye drops will relieve the itchiness.
It is important to note that individual responses to ketamine can vary, and not everyone experiences the same side effects. If you are concerned about itchy eyes or any other side effects during ketamine therapy, consult your healthcare provider for personalized advice and potential adjustments to your treatment plan.